Cardioprotective Effect of the Selective Sigma-1 Receptor Agonist, SA4503
نویسندگان
چکیده
منابع مشابه
[Cardioprotective effect of the selective sigma-1 receptor agonist, SA4503].
We previously reported that the sigma-1 receptor is down-regulated in cardiomyocytes following heart failure in transverse aortic constriction (TAC) mice. In this review, we summarized the anti-hypertrophic action of selective sigma-1 receptor agonist, SA4503 in the hypertrophied cultured cardiomyocytes and discussed its possible mechanism of cardioprotection. Treatment with SA4503 (0.1-1 μM) d...
متن کاملPhase II trial of the Sigma-1 receptor agonist cutamesine (SA4503) for recovery enhancement after acute ischemic stroke.
BACKGROUND AND PURPOSE The σ-1 receptor (Sig-1R) agonist cutamesine (SA4503) enhanced functional recovery after experimental stroke with a treatment initiation window of 48 hours and chronic treatment for 28 days. We conducted a phase 2 clinical trial exploring the safety, tolerability, dose range, and functional effects of cutamesine in patients with ischemic stroke. METHODS Subjects were ra...
متن کاملPreliminary Communication Repeated Treatment with Sa4503, a Selective Sigma1 Receptor Agonist, Up-regulates 1-adrenergic System. a Behavioral Study
SA4503 [1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride] has been described as a new, selective sigma ( ) receptor agonist with a potential antidepressant activity [8, 9, 17]. It has been reported that SA4503 shows an antidepressant-like activity in mice [8, 17]. Similar effects were observed after the administration of (+)-pentazocine (another receptor agonist) and DTG ...
متن کاملThe effect of intrahippocampal injection of diarylpropionitrile, a selective estrogen receptor-beta agonist, on passive avoidance learning
Introduction: Neurohormones like testosterone and estradiol have an important role in learning and memory. The hippocampus is essentially involved in learning and memory, and is known to be a target for estradiol actions. Estrogen receptors (ERs) are highly expressed in CA1 of rat hippocampus, and mediate the effects of estrogen on learning and memory. Estradiol receptor belong to a family ...
متن کاملCardioprotective effects of a selective B(2) receptor agonist of bradykinin post-acute myocardial infarct.
BACKGROUND The cardioprotective benefits of bradykinin are attributable to activation of its B(2) receptor (B(2)R)-mediated actions and abolished by B(2)R antagonists. The current experiments evaluated the cardioprotective potential of a potent, long-acting B(2)R-selective agonist peptide analogue of bradykinin, the compound NG291. METHODS We compared the extent of cardiac tissue damage and r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2014
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.13-00255-3